Recent Work by NORCH Investigators
Childhood undernutrition and growth impairment remain substantial burdens in Sub-Saharan Africa. Environmental enteric dysfunction (EED), a subclinical condition associated with inflammation and malabsorpition in the small intestine, is associated with growth failure. As several studies have demonstrated that individuals with low weight in early childhood are at risk for cardiometabolic disease later in life, NORCH Associate Director Dr. Christopher P. Duggan, NORCH member Dr. Wafaie Fawzi, and others recently investigated whether EED in infancy is associated with cardiovascular risk measures in mid-childhood. Anti-flagellin IgA is a marker for EED and is significantly higher in Tanzanian infants compared to infants in Boston. Drs. Duggan, Fawzie, et al. demonstrated that flagellin IgA at 6 weeks of age is associated with both systolic and diastolic blood pressure in mid-childhood
Recent Work by NORCH Investigators
With support from a NORCH Pilot and Feasibility Grant, Dr. Lauren Feichtner and others recently reported that gestational weight gain affects the composition and diversity of the infant gut microbiome. Using data and infant fecal samples from 84 infant-mother pairs, four distinct microbiota profiles were identified: Bifidobacterium-dominant, Enterobacter/Veillonella-dominant, Bacteroides-dominant, and Escherichia-dominant. Infants whose mothers had more weight gain during pregnancy were less likely to have a Bacteroides-dominant profile (risk ratio 0.83 [95% CI 0.71-0.96] per 1kg of gestational weight gain). Further, a larger amount of gestational weight gain predicted lower bacterial diversity.
Adipose Tissue-Derived miRNAs Regulate Gene Expression in Other Tissues
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate translation and thereby contribute to the regulation of metabolic processes. Dr. Kahn and others recently demonstrated in Nature that adipose tissue is an important source of circulating miRNAs. Mice with an adipose-tissue-specific knockout of the miRNA processing enzyme Dicer (ADicerKO) demonstrated substantial reductions in levels of circulating miRNAs, and fat transplant from wild type animals largely restored miRNA levels.
21st Annual NORCH Symposium on NAFLD!
Pilot & Feasibility RFA!
The NORC at Harvard is delighted to announce special Pilot & Feasibility Award for translational research investigating how obesity and/or metabolic processes moderate infection rate, illness severity, outcome, or long-term sequelae of COVID-19. For more information on the application for our COVID RFA and submissions please visit our Application Procedure sub-tab under the main P+F Projects tab on this website!
Outstanding Mentor Award Nominations!
The NORC at Harvard is delighted to announce an Outstanding Mentor Award to be given to a faculty member who has provided meaningful sustained mentorship to young investigators in the fields of nutrition, obesity, and metabolism. For more information on our Outstanding Mentor Award and Nominations, please visit our Resources sub-tab under the main Home tab on this website!
Pilot & Feasibility Application!
DEADLINE CLOSED: Thank for another incredibly successful application year! For more information on the application for our P+F Award and submissions please visit our Application Procedure sub-tab under the main P+F Projects tab on this website!
Outstanding Manuscript Nominations!
DEADLINE CLOSED: Thank you for all the nominations! We will be announcing the winner at our Symposium on June 30th. For more information on our Outstanding Manuscript Award and Nominations, please visit our Resources sub-tab under the main Home tab on this website!
Please Cite the Grant!
Due to potential residual travel and meeting restrictions due to COVID-19, we will be changing our annual symposium to VIRTUAL! Please register on Eventbrite to ensure that the link to the symposium’s livestream will be sent to you via email in the days leading up to the symposium itself! Please go register for our 21st Annual NORCH Symposium presenting Nonalcoholic Fatty Liver Disease (NAFLD): Mechanisms and Novel Therapeutics via this link!
The symposium will take place on Tuesday, June 30th, 2020.
This event will be ALL DAY. For more information please visit the 2020 Symposium tab on this website.